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cenobamate will boost the level or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Contemplate a dose reduction of CYP2C19 substrates, as clinically ideal, when used concomitantly with cenobamate.butabarbital will reduce the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A